The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae.
Identifieur interne : 001247 ( Main/Exploration ); précédent : 001246; suivant : 001248The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae.
Auteurs : Cheol Woong Ha [Corée du Sud] ; Won-Ki HuhSource :
- Aging [ 1945-4589 ] ; 2011.
Descripteurs français
- KwdFr :
- ADN fongique (génétique), ADN fongique (métabolisme), ADN ribosomique (génétique), ADN ribosomique (métabolisme), Instabilité du génome (MeSH), Modèles biologiques (MeSH), Protein-Serine-Threonine Kinases (antagonistes et inhibiteurs), Protein-Serine-Threonine Kinases (métabolisme), Protéines SIR de Saccharomyces cerevisiae (génétique), Protéines SIR de Saccharomyces cerevisiae (métabolisme), Protéines de Saccharomyces cerevisiae (antagonistes et inhibiteurs), Protéines de Saccharomyces cerevisiae (métabolisme), Saccharomyces cerevisiae (croissance et développement), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Sirtuine-2 (génétique), Sirtuine-2 (métabolisme), Sumoylation (MeSH), Transduction du signal (MeSH), Épigenèse génétique (MeSH).
- MESH :
- antagonistes et inhibiteurs : Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae.
- croissance et développement : Saccharomyces cerevisiae.
- génétique : ADN fongique, ADN ribosomique, Protéines SIR de Saccharomyces cerevisiae, Saccharomyces cerevisiae, Sirtuine-2.
- métabolisme : ADN fongique, ADN ribosomique, Protein-Serine-Threonine Kinases, Protéines SIR de Saccharomyces cerevisiae, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae, Sirtuine-2.
- Instabilité du génome, Modèles biologiques, Sumoylation, Transduction du signal, Épigenèse génétique.
English descriptors
- KwdEn :
- DNA, Fungal (genetics), DNA, Fungal (metabolism), DNA, Ribosomal (genetics), DNA, Ribosomal (metabolism), Epigenesis, Genetic (MeSH), Genomic Instability (MeSH), Models, Biological (MeSH), Protein-Serine-Threonine Kinases (antagonists & inhibitors), Protein-Serine-Threonine Kinases (metabolism), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (antagonists & inhibitors), Saccharomyces cerevisiae Proteins (metabolism), Signal Transduction (MeSH), Silent Information Regulator Proteins, Saccharomyces cerevisiae (genetics), Silent Information Regulator Proteins, Saccharomyces cerevisiae (metabolism), Sirtuin 2 (genetics), Sirtuin 2 (metabolism), Sumoylation (MeSH).
- MESH :
- chemical , antagonists & inhibitors : Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins.
- chemical , genetics : DNA, Fungal, DNA, Ribosomal, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Sirtuin 2.
- chemical , metabolism : DNA, Fungal, DNA, Ribosomal, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Sirtuin 2.
- genetics : Saccharomyces cerevisiae.
- growth & development : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae.
- Epigenesis, Genetic, Genomic Instability, Models, Biological, Signal Transduction, Sumoylation.
Abstract
The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibition. Here we review the implication of rDNA stabilizers in longevity, discuss how Sir2 stabilizes rDNA under TOR inhibition and speculate on the link between sumoylation and Sir2-related pro-aging pathways.
DOI: 10.18632/aging.100299
PubMed: 21415463
PubMed Central: PMC3091525
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibition. Here we review the implication of rDNA stabilizers in longevity, discuss how Sir2 stabilizes rDNA under TOR inhibition and speculate on the link between sumoylation and Sir2-related pro-aging pathways.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21415463</PMID><DateCompleted><Year>2011</Year><Month>08</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1945-4589</ISSN><JournalIssue CitedMedium="Internet"><Volume>3</Volume><Issue>3</Issue><PubDate><Year>2011</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Aging</Title><ISOAbbreviation>Aging (Albany NY)</ISOAbbreviation></Journal><ArticleTitle>The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae.</ArticleTitle><Pagination><MedlinePgn>319-24</MedlinePgn></Pagination><Abstract><AbstractText>The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibition. Here we review the implication of rDNA stabilizers in longevity, discuss how Sir2 stabilizes rDNA under TOR inhibition and speculate on the link between sumoylation and Sir2-related pro-aging pathways.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ha</LastName><ForeName>Cheol Woong</ForeName><Initials>CW</Initials><AffiliationInfo><Affiliation>School of Biological Sciences, Research Center for Functional Cellulomics, Institute of Microbiology, Seoul National University, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huh</LastName><ForeName>Won-Ki</ForeName><Initials>WK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United 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